Description

tert-Butyl n-(5-Bromo-3-Ethynylpyrazin-2-Yl)-n-[(tert-Butoxy)Carbonyl]Carbamate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for medicinal chemistry research and development, particularly in constructing novel heterocyclic scaffolds. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers specializing in oncology, antiviral, and other therapeutic areas requiring sophisticated pyrazine-based molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its reactive bromo and ethynyl functional groups.
• API Development: Serves as a precursor in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Employed in the development of molecular probes for studying biological pathways, leveraging its potential for click chemistry via the alkyne moiety.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.
• Academic Research: Used in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Item	Details
Product Name	tert-Butyl n-(5-Bromo-3-Ethynylpyrazin-2-Yl)-n-[(tert-Butoxy)Carbonyl]Carbamate
CAS No.	1232423-55-0
Molecular Formula	C16H20BrN3O4
Molecular Weight	398.25 g/mol
Synonyms	Boc-Protected 5-Bromo-3-ethynylpyrazin-2-amine; tert-Butyl (5-bromo-3-ethynylpyrazin-2-yl)(tert-butoxycarbonyl)carbamate; 5-Bromo-3-ethynylpyrazin-2-amine N-Boc derivative; 2-[(tert-Butoxycarbonyl)amino]-5-bromo-3-ethynylpyrazine-1-carboxylic acid tert-butyl ester; 1232423-55-0; tert-Butyl N-(5-bromo-3-ethynyl-2-pyrazinyl)-N-[(tert-butoxy)carbonyl]carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl n-(5-Bromo-3-Ethynylpyrazin-2-Yl)-n-[(tert-Butoxy)Carbonyl]Carbamate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.