Description

trans-4-Amino-1-Boc-3-Methoxypiperidine is a high-purity, protected piperidine derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile, stereochemically defined scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for API synthesis.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and combinatorial chemistry libraries to explore new therapeutic entities.
• Process Chemistry & Scale-up: Serves as a starting material or intermediate in the optimization and commercial-scale synthesis of target molecules.
• Agrochemical Synthesis: Building block for creating novel pesticides and herbicides with specific stereochemical requirements.
• Ligand & Catalyst Development: Precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke chemical synthesis projects.

Basic Information

Product Name	trans-4-Amino-1-Boc-3-Methoxypiperidine
CAS No.	1232059-97-0
Molecular Formula	C11H22N2O3
Molecular Weight	230.31 g/mol
Synonyms	1-Boc-3-methoxy-4-aminopiperidine; tert-Butyl 4-amino-3-methoxypiperidine-1-carboxylate; 4-Amino-3-methoxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 3-Methoxy-4-aminopiperidine-1-carboxylic acid tert-butyl ester; trans-1-N-Boc-3-methoxy-4-aminopiperidine; (3R,4R)-1-(tert-Butoxycarbonyl)-3-methoxy-4-aminopiperidine; (3S,4S)-1-(tert-Butoxycarbonyl)-3-methoxy-4-aminopiperidine; trans-4-Amino-1-(tert-butoxycarbonyl)-3-methoxypiperidine
EINECS	Contact for details

Quality Control

Our trans-4-Amino-1-Boc-3-Methoxypiperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de (trans isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.