Description

2,3-Dihydro-Pyrazine-1,4-Dicarboxylic Acid 1-Benzyl Ester 4-tert-Butyl Ester is a high-purity, synthetically valuable protected diacid derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in providing a versatile and reactive scaffold for constructing complex nitrogen-containing heterocycles, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process R&D teams in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for API synthesis and novel molecule discovery.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel pyrazine and piperazine-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile building block for constructing focused libraries and exploring structure-activity relationships (SAR) in drug discovery programs.
• Agrochemical Synthesis: Intermediate for developing new herbicides, fungicides, and insecticides containing the dihydropyrazine core.
• Peptidomimetic Development: Used to introduce constrained, heterocyclic diacid motifs into peptide backbones to enhance stability and biological activity.
• Ligand and Catalyst Design: Foundation for creating novel chelating ligands and organocatalysts used in asymmetric synthesis.
• Polymer Chemistry: Monomer or co-monomer for synthesizing specialty polymers with unique thermal or electronic properties.

Basic Information

Product Name	2,3-Dihydro-Pyrazine-1,4-Dicarboxylic Acid 1-Benzyl Ester 4-tert-Butyl Ester
CAS No.	1228675-27-1
Molecular Formula	C18H24N2O4
Molecular Weight	332.40 g/mol
Synonyms	1-Benzyl 4-tert-butyl 2,3-dihydropyrazine-1,4-dicarboxylate; 1,4-Dicarboxylic Acid, 2,3-Dihydro-Pyrazine-, 1-Benzyl Ester 4-tert-Butyl Ester; 2,3-Dihydro-1H-pyrazine-1,4-dicarboxylic acid, 1-(phenylmethyl) 4-(1,1-dimethylethyl) ester; Benzyl tert-butyl 2,3-dihydropyrazine-1,4-dicarboxylate; 1-Benzyl 4-(tert-butyl) 2,3-dihydropyrazine-1,4-dicarboxylate; Protected DHPZ diacid; DHPZ(Bn)(tBu) diester
EINECS	Contact for details

Quality Control

Our 2,3-Dihydro-Pyrazine-1,4-Dicarboxylic Acid 1-Benzyl Ester 4-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.