Description

(E)-Methyl 3-(1-Pivaloyl-2,3-Dihydro-1H-Pyrido[2,3-B][1,4]Oxazin-6-Yl)Acrylate is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic acrylate structure. This compound is of significant commercial value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting specific enzyme pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Used in the final stages or penultimate steps for constructing the core pharmacophore of target molecules.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for scale-up and cGMP production.
• Chemical Biology Probes: Can be utilized to develop tool compounds for investigating biological mechanisms and target validation.

Basic Information

Product Name	(E)-Methyl 3-(1-Pivaloyl-2,3-Dihydro-1H-Pyrido[2,3-B][1,4]Oxazin-6-Yl)Acrylate
CAS No.	1228670-39-0
Molecular Formula	C18H22N2O4
Molecular Weight	330.38 g/mol
Synonyms	Methyl (2E)-3-[1-(2,2-dimethylpropanoyl)-2,3-dihydro-4H-pyrido[2,3-b][1,4]oxazin-6-yl]prop-2-enoate; Methyl (E)-3-(1-Pivaloyl-3,4-dihydro-2H-pyrido[2,3-b][1,4]oxazin-6-yl)acrylate; 1-Pivaloyl-6-[(1E)-3-methoxy-3-oxo-1-propen-1-yl]-3,4-dihydro-2H-pyrido[2,3-b][1,4]oxazine; CAS 1228670-39-0; Pivaloyl DHPO Acrylate Ester
EINECS	Contact for details

Quality Control

Our production of (E)-Methyl 3-(1-Pivaloyl-2,3-Dihydro-1H-Pyrido[2,3-B][1,4]Oxazin-6-Yl)Acrylate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.