Description

(E)-Methyl 3-(2-Amino-5-Fluoropyridin-3-Yl)-Acrylate is a high-value fluorinated pyridine derivative and a key pharmaceutical intermediate. This compound matters for its role as a versatile building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in kinase inhibitor development. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for advanced organic synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides containing fluoropyridine motifs.
• Fine Chemical Building Block: Serves as a versatile scaffold for constructing complex molecules in research and development.
• Material Science Research: Investigated for the creation of novel organic electronic materials and liquid crystals.
• Bioconjugation Chemistry: The acrylate moiety can be utilized for Michael addition reactions in bioconjugate and probe synthesis.

Basic Information

Product Name	(E)-Methyl 3-(2-Amino-5-Fluoropyridin-3-Yl)-Acrylate
CAS No.	1228670-23-2
Molecular Formula	C9H9FN2O2
Molecular Weight	196.18 g/mol
Synonyms	Methyl (2E)-3-(2-Amino-5-fluoro-3-pyridinyl)-2-propenoate; (E)-Methyl 3-(2-amino-5-fluoropyridin-3-yl)acrylate; 2-Propenoic acid, 3-(2-amino-5-fluoro-3-pyridinyl)-, methyl ester, (2E)-; Methyl (E)-3-(2-Amino-5-fluoropyridin-3-yl)acrylate; 3-Pyridineacrylic acid, 2-amino-5-fluoro-, methyl ester, (E)-; 1228670-23-2; (E)-Methyl 3-(2-Amino-5-fluoropyridin-3-yl)prop-2-enoate
EINECS	Contact for details

Quality Control

Our (E)-Methyl 3-(2-Amino-5-Fluoropyridin-3-Yl)-Acrylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with full traceability are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.