Description

(E)-tert-Butyl 4-Chloro-3-((Hydroxyimino)Methyl)-Pyridin-2-Ylcarbamate CAS NO 1228670-07-2 is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs.

Application

This specialized intermediate serves as a key building block in sophisticated organic synthesis. Its primary applications include:

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of target drug molecules, especially those with pyridine-based cores.
• API Development: Used in research and development for constructing complex molecular scaffolds in new chemical entities (NCEs).
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes due to its reactive oxime and carbamate functionalities.
• Custom Synthesis: Serves as a starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	(E)-tert-Butyl 4-Chloro-3-((Hydroxyimino)Methyl)-Pyridin-2-Ylcarbamate
CAS No.	1228670-07-2
Molecular Formula	C12H16ClN3O3
Molecular Weight	285.73 g/mol
Synonyms	tert-Butyl (E)-4-chloro-3-[(hydroxyimino)methyl]pyridin-2-ylcarbamate; 2-Pyridinecarboxamide, 4-chloro-3-[(hydroxyimino)methyl]-N-(1,1-dimethylethyl)-, (3E)-; (E)-tert-Butyl 4-chloro-3-(hydroxyiminomethyl)pyridin-2-ylcarbamate; 4-Chloro-3-((hydroxyimino)methyl)-N-(tert-butoxycarbonyl)pyridin-2-amine; Boc-protected 4-chloro-3-formylpyridine oxime; 1228670-07-2; Carbamic acid, N-(4-chloro-3-((hydroxyimino)methyl)-2-pyridinyl)-, 1,1-dimethylethyl ester, (E)-
EINECS	Contact for details

Quality Control

Our production of (E)-tert-Butyl 4-Chloro-3-((Hydroxyimino)Methyl)-Pyridin-2-Ylcarbamate adheres to stringent quality management systems. The material is manufactured and controlled under current Good Manufacturing Practice (cGMP) principles suitable for pharmaceutical development. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment to ensure full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The container should be kept tightly sealed to protect from moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.