Description

3-Chloro-2-Fluoro-4-Iodo-6-(Pyrrolidin-1-Yl)-Pyridine is a high-value, multi-halogenated pyridine derivative designed for advanced chemical synthesis. This compound serves as a critical building block in pharmaceutical and agrochemical research, enabling the rapid construction of complex molecular architectures. It is primarily sought by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active molecule development.
• Agrochemical Research: Used to construct novel pyridine-based herbicides, fungicides, and insecticides with tailored biological activity.
• Material Science: Building block for creating functionalized ligands in catalysis and for developing advanced organic electronic materials.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for selective Suzuki, Stille, and Buchwald-Hartwig amination reactions.
• Chemical Biology: Useful as a probe or tag in medicinal chemistry due to its distinct halogen pattern and pyrrolidine moiety.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Item	Detail
Product Name	3-Chloro-2-Fluoro-4-Iodo-6-(Pyrrolidin-1-Yl)-Pyridine
CAS No.	1228666-54-3
Molecular Formula	C9H7ClFIN2
Molecular Weight	340.52 g/mol
Synonyms	3-Chloro-2-fluoro-4-iodo-6-(pyrrolidin-1-yl)pyridine; 6-(Pyrrolidin-1-yl)-3-chloro-2-fluoro-4-iodopyridine; 2-Fluoro-3-chloro-4-iodo-6-pyrrolidin-1-ylpyridine; 1228666-54-3; 3-Chloro-2-fluoro-4-iodo-6-(1-pyrrolidinyl)pyridine; Pyridine, 3-chloro-2-fluoro-4-iodo-6-(1-pyrrolidinyl)-; SCHEMBL21806227; ACH-00002939
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-2-Fluoro-4-Iodo-6-(Pyrrolidin-1-Yl)-Pyridine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat and incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.