Description

1-(6-Bromo-2,3-Dihydro-1H-Pyrido[2,3-B][1,4]-Oxazin-1-Yl)-2,2-Dimethylpropan-1-One is a high-purity, advanced pharmaceutical intermediate designed for complex synthesis pathways. This compound is critical for research and development in medicinal chemistry, offering a key structural motif for constructing novel active molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutic agents, particularly in oncology and CNS drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel drug candidates, especially for targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Active Pharmaceutical Ingredient (API) Development: A key precursor in the multi-step synthesis of complex, high-value APIs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development.
• Oncology & CNS Drug Discovery: Its fused heterocyclic structure makes it valuable for creating molecules targeting specific biological pathways.
• Process Chemistry & Scale-Up: Supports the transition from laboratory-scale research to pilot and commercial manufacturing.

Basic Information

Product Name	1-(6-Bromo-2,3-Dihydro-1H-Pyrido[2,3-B][1,4]-Oxazin-1-Yl)-2,2-Dimethylpropan-1-One
CAS No.	1228666-49-6
Molecular Formula	C14H17BrN2O2
Molecular Weight	325.20 g/mol
Synonyms	1-(6-Bromo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-1-yl)-2,2-dimethylpropan-1-one; 6-Bromo-1-(2,2-dimethylpropanoyl)-1,2,3,4-tetrahydropyrido[2,3-b][1,4]oxazine; 1228666-49-6; Pivaloyl derivative of 6-bromo-1,2,3,4-tetrahydropyrido[2,3-b][1,4]oxazine; 6-Bromo-1-pivaloyl-1,2,3,4-tetrahydropyrido[2,3-b][1,4]oxazine
EINECS	Contact for details

Quality Control

Our 1-(6-Bromo-2,3-Dihydro-1H-Pyrido[2,3-B][1,4]-Oxazin-1-Yl)-2,2-Dimethylpropan-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.