Description

3-Bromo-2-Fluoro-6-(Pyrrolidin-1-Yl)Pyridine is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. Its core value lies in the strategic combination of halogen substituents and a pyrrolidine ring, offering versatile reactivity for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate in the development of new active ingredients.

Application

• As a versatile pharmaceutical intermediate in the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) targeted research.
• Key building block for constructing agrochemicals, including potential herbicides and fungicides, leveraging its halogenated pyridine core.
• Used in material science for the development of organic semiconductors, ligands, and functional polymers.
• Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) where the bromo and fluoro groups offer orthogonal reactivity for sequential functionalization.
• Serves as a precursor for libraries in medicinal chemistry via further derivatization of the pyrrolidine nitrogen or the pyridine ring.
• Useful in academic and R&D settings for studying structure-activity relationships (SAR) and novel heterocyclic chemistry.

Basic Information

Product Name	3-Bromo-2-Fluoro-6-(Pyrrolidin-1-Yl)Pyridine
CAS No.	1228666-43-0
Molecular Formula	C9H10BrFN2
Molecular Weight	245.10 g/mol
Synonyms	3-Bromo-2-fluoro-6-(1-pyrrolidinyl)pyridine; 6-(Pyrrolidin-1-yl)-3-bromo-2-fluoropyridine; 2-Fluoro-3-bromo-6-pyrrolidin-1-ylpyridine; 3-Bromo-2-fluoro-6-pyrrolidin-1-ylpyridine; Pyridine, 3-bromo-2-fluoro-6-(1-pyrrolidinyl)-; 1228666-43-0
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Fluoro-6-(Pyrrolidin-1-Yl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for critical R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.