Description

5-Fluoro-1H-Pyrrolo[2,3-B]Pyridine-4-Carboxylic Acid is a high-value heterocyclic building block essential for modern pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor programs. It is primarily utilized by medicinal chemists and process development scientists within the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Process R&D: Serves as a starting material or advanced intermediate in the development of scalable commercial synthetic routes for APIs.
• Bioconjugation: The carboxylic acid functional group allows for coupling reactions to create targeted drug conjugates or probes.
• Chemical Biology: Employed in the design and synthesis of chemical tools and probes for studying biological pathways and target engagement.
• Custom Synthesis: A foundational component for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	5-Fluoro-1H-Pyrrolo[2,3-B]Pyridine-4-Carboxylic Acid
CAS No.	1228666-41-8
Molecular Formula	C8H5FN2O2
Molecular Weight	180.14 g/mol
Synonyms	4-Carboxy-5-fluoro-1H-pyrrolo[2,3-b]pyridine; 5-Fluoro-4-carboxy-1H-pyrrolo[2,3-b]pyridine; 5-Fluoro-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid; 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 5-fluoro-; 5-Fluoro-4-pyridinecarboxylic acid, 1H-pyrrolo[2,3-b]pyridine; 1228666-41-8; 5-Fluoro-1H-pyrrolo[2,3-b]pyridine-4-carboxylate
EINECS	Contact for details

Quality Control

Our 5-Fluoro-1H-Pyrrolo[2,3-B]Pyridine-4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are provided for each lot to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.