Description

8-Iodo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine is a specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders or infectious diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, or insecticides, leveraging its unique fused-ring iodine-substituted structure.
• Ligand & Catalyst Development: Acts as a scaffold for creating novel ligands in transition metal catalysis or organocatalysis due to the presence of iodine and heteroatoms.
• Material Science Precursor: Employed in the synthesis of organic electronic materials, such as charge-transport molecules or photoactive compounds.
• Chemical Biology Probe Synthesis: Utilized to create molecular probes for studying biological pathways and protein interactions.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form more complex biaryl or alkyne structures.

Basic Information

Product Name	8-Iodo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine
CAS No.	1228666-17-8
Molecular Formula	C9H8INO2
Molecular Weight	289.07 g/mol
Synonyms	8-Iodo-2,3-dihydro[1,4]dioxino[2,3-b]pyridine; [1,4]Dioxino[2,3-b]pyridine, 8-iodo-2,3-dihydro-; 2,3-Dihydro-8-iodo[1,4]dioxino[2,3-b]pyridine; 8-Iodo-2,3-dihydro-1,4-dioxino[2,3-b]pyridine; 8-Iododioxinopyridine; Iododioxinopyridine derivative; Fused dioxinopyridine iodide; Contact for EINECS details.

Quality Control

Our 8-Iodo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is light-sensitive (store away from light). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.