Description

tert-Butyl 4-Chloro-2-(3-Hydroxyprop-1-Ynyl)-Pyridin-3-Yl Carbonate is a high-purity, advanced pharmaceutical intermediate featuring a unique pyridine scaffold with chloro, propargyl alcohol, and tert-butyl carbonate protecting groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with precise structural control. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the development of new active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and targeted therapy research.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex heterocyclic cores in drug discovery programs.
• Kinase Inhibitor Synthesis: Serves as a versatile precursor in the development of potent and selective kinase inhibitors for oncology and inflammatory diseases.
• Protecting Group Chemistry: The tert-butyl carbonate (Boc) group provides a stable, orthogonal protecting strategy for amine functionalities in multi-step syntheses.
• Click Chemistry Substrate: The terminal alkyne moiety allows for efficient, copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation or library synthesis.
• Medicinal Chemistry SAR Studies: Used to explore structure-activity relationships by introducing modifications at the chloro, hydroxyl, or alkyne positions.
• Process Chemistry & Scale-Up: Suitable for optimization and scaling in GMP or non-GMP environments for clinical trial material production.

Basic Information

Product Name	tert-Butyl 4-Chloro-2-(3-Hydroxyprop-1-Ynyl)-Pyridin-3-Yl Carbonate
CAS No.	1228665-84-6
Molecular Formula	C13H14ClNO3
Molecular Weight	267.71 g/mol
Synonyms	3-Pyridinecarboxylic acid, 4-chloro-2-(3-hydroxy-1-propyn-1-yl)-, 1,1-dimethylethyl ester; 4-Chloro-2-(3-hydroxyprop-1-yn-1-yl)pyridin-3-yl tert-butyl carbonate; tert-Butyl 4-chloro-2-(3-hydroxyprop-1-yn-1-yl)pyridine-3-carboxylate; 1228665-84-6; BOC-protected 4-chloro-2-propynyl alcohol pyridine derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Chloro-2-(3-Hydroxyprop-1-Ynyl)-Pyridin-3-Yl Carbonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.