Description

2-Fluoro-4-Iodo-6-(Pyrrolidin-1-Yl)Pyridine is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. Its unique halogenated pyridine core, functionalized with fluorine, iodine, and a pyrrolidine group, makes it an indispensable intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for drug discovery, lead optimization, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides due to its bioactive pyridine scaffold.
• Material Science Precursor: Serves as a monomer or functionalizing agent for creating specialty polymers and organic electronic materials.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Negishi couplings.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and fragment-based drug design to explore new chemical space.
• Chemical Biology Probes: Used to create labeled compounds or probes for studying biological pathways and target engagement.

Basic Information

Product Name	2-Fluoro-4-Iodo-6-(Pyrrolidin-1-Yl)Pyridine
CAS No.	1228665-69-7
Molecular Formula	C9H10FIN2
Molecular Weight	292.10 g/mol
Synonyms	2-Fluoro-4-iodo-6-(1-pyrrolidinyl)pyridine; 6-(Pyrrolidin-1-yl)-2-fluoro-4-iodopyridine; 4-Iodo-2-fluoro-6-pyrrolidin-1-ylpyridine; 2-Fluoro-4-iodo-6-pyrrolidin-1-ylpyridine; Pyridine, 2-fluoro-4-iodo-6-(1-pyrrolidinyl)-; CAS 1228665-69-7
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-4-Iodo-6-(Pyrrolidin-1-Yl)Pyridine is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.