Description

5-Fluoro-6-Iodo-1H-Pyrrolo[2,3-B]Pyridine is a high-value, halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular scaffold, which serves as a versatile intermediate for constructing complex pharmacophores and functional materials. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small molecule drugs, particularly kinase inhibitors and other biologically active compounds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides due to its halogenated pyrrolopyridine structure.
• Material Science: Serves as a building block for creating organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology: Employed as a molecular probe or a tagged fragment in drug discovery and proteomics research.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Library Synthesis: Used in parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	5-Fluoro-6-Iodo-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1228665-63-1
Molecular Formula	C7H4FIN2
Molecular Weight	277.02 g/mol
Synonyms	6-Iodo-5-fluoro-1H-pyrrolo[2,3-b]pyridine; 5-Fluoro-6-iodo-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-6-iodo-; 5-Fluoro-6-iodo-7-azaindole; 6-Iodo-5-fluoro-7-azaindole; 5-F-6-I-1H-Pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 5-Fluoro-6-Iodo-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed in a dry, inert atmosphere to maximize long-term stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.