Description

6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoronicotinaldehyde is a high-value, advanced pharmaceutical intermediate featuring a unique pyrrolidine scaffold protected by a tert-butyldimethylsilyl (TBDMS) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex small-molecule active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its modifiable aldehyde and fluoropyridine functionalities.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker component in the design of bifunctional degraders.
• Kinase Inhibitor Synthesis: Incorporated into the core structure of inhibitors targeting specific protein kinases.
• Chemical Biology Probes: Utilized for creating labeled or tagged molecules to study biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP or research-grade conditions.

Basic Information

Product Name	6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoronicotinaldehyde
CAS No.	1228665-60-8
Molecular Formula	C17H27FN2O2Si
Molecular Weight	338.50 g/mol
Synonyms	2-Fluoro-6-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-pyrrolidinyl]-3-pyridinecarboxaldehyde; 2-Fluoro-6-(3-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-1-yl)nicotinaldehyde; 6-(3-((Tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoropyridine-3-Carbaldehyde; TBDMS-protected fluoronicotinaldehyde pyrrolidine intermediate; 1228665-60-8
EINECS	Contact for details

Quality Control

Our production of 6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoronicotinaldehyde adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive R&D applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development under quality agreements and can supply material suitable for use in cGMP-regulated environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.