Description

(6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoropyridin-3-Yl)Methanol is a sophisticated, high-purity pharmaceutical intermediate featuring a unique pyrrolidine-pyridine scaffold with protective silyl ether and fluorinated aromatic moieties. This compound is of critical importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the discovery and process development of new drugs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in early-stage drug discovery programs.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for potential APIs under Good Manufacturing Practice (GMP) conditions.
• Protecting Group Strategy: The tert-butyldimethylsilyl (TBDMS) protecting group allows for selective reactions elsewhere on the molecule, which is later cleaved under controlled conditions.
• Fluorinated Compound Synthesis: The 2-fluoropyridine moiety is a valuable pharmacophore, making this intermediate essential for introducing fluorine atoms to modulate a drug's metabolic stability, bioavailability, and binding affinity.

Basic Information

Item	Details
Product Name	(6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoropyridin-3-Yl)Methanol
CAS No.	1228665-50-6
Molecular Formula	C17H29FN2O2Si
Molecular Weight	340.51 g/mol
Synonyms	(6-(3-((tert-Butyldimethylsilyl)oxymethyl)pyrrolidin-1-yl)-2-fluoropyridin-3-yl)methanol; (6-(3-((TBDMS-Oxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoropyridin-3-Yl)Methanol; 2-Fluoro-6-(3-((((1,1-dimethylethyl)dimethylsilyl)oxy)methyl)-1-pyrrolidinyl)-3-pyridinemethanol; 3-Pyridinemethanol, 2-fluoro-6-[3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-pyrrolidinyl]-; TBDMS-protected fluoropyridinyl pyrrolidine methanol; CAS 1228665-50-6
EINECS	Contact for details

Quality Control

Our (6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoropyridin-3-Yl)Methanol is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the exacting standards required for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We support development under GMP guidelines for advanced projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); ensure containers are sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.