Description

T-Butyl 6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoropyridin-3-Ylcarbamate is a sophisticated, multi-functional chemical intermediate designed for advanced pharmaceutical synthesis. This compound is critical for researchers and manufacturers requiring high-purity building blocks for complex active pharmaceutical ingredients (APIs). It is primarily utilized in the development of novel therapeutic agents, particularly within medicinal chemistry and process R&D for life sciences.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new therapeutic targets.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Proteolysis Targeting Chimera (PROTAC) Synthesis: Potential use in constructing advanced bifunctional molecules for targeted protein degradation.
• Kinase Inhibitor Development: Intermediate in the synthesis of selective kinase inhibitors for oncology and inflammatory diseases.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and reference standards.

Basic Information

Product Name	T-Butyl 6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoropyridin-3-Ylcarbamate
CAS No.	1228665-49-3
Molecular Formula	C20H34FN3O3Si
Molecular Weight	411.59 g/mol
Synonyms	tert-Butyl 6-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-pyrrolidinyl]-2-fluoro-3-pyridinecarboxylate; 2-Fluoro-6-(3-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)nicotinic acid tert-butyl ester; 6-(3-((tert-Butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)-2-fluoropyridine-3-carboxylic acid tert-butyl ester; TBDMS-protected pyrrolidine-fluoropyridine carbamate; 1228665-49-3; tert-Butyl 6-(3-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-1-yl)-2-fluoronicotinate
EINECS	Contact for details

Quality Control

Our T-Butyl 6-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Fluoropyridin-3-Ylcarbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, NMR, and MS. We support compliance with ICH Q7 guidelines and can provide material for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Single Maximum Impurity	≤1.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.