Description

2-Fluoro-6-(Pyrrolidin-1-Yl)-4-((Trimethylsilyl)-Ethynyl)Pyridine is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound matters for its unique molecular architecture, combining a fluorinated pyridine core with a pyrrolidine substituent and a protected ethynyl group, enabling precise molecular modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound libraries.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized ligands in catalysis or as a building block for advanced organic electronic materials.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules for studying biological pathways and protein interactions due to its modifiable alkyne handle.
• Cross-Coupling Reactions: The trimethylsilyl-protected alkyne and halogenated pyridine ring make it an excellent substrate for Sonogashira, Suzuki, and other palladium-catalyzed cross-coupling reactions.

Basic Information

Product Name	2-Fluoro-6-(Pyrrolidin-1-Yl)-4-((Trimethylsilyl)-Ethynyl)Pyridine
CAS No.	1228665-47-1
Molecular Formula	C14H19FN2Si
Molecular Weight	262.40 g/mol
Synonyms	4-((Trimethylsilyl)ethynyl)-2-fluoro-6-(pyrrolidin-1-yl)pyridine; 2-Fluoro-6-(1-pyrrolidinyl)-4-[(trimethylsilyl)ethynyl]pyridine; 2-Fluoro-4-((trimethylsilyl)ethynyl)-6-(pyrrolidin-1-yl)pyridine; 4-((Trimethylsilyl)ethynyl)-2-fluoro-6-(pyrrolidin-1-yl)pyridine; 1228665-47-1; TMS-protected fluoro-pyridine alkyne; Pyrrolidinyl-fluoro-TMS-alkyne pyridine
EINECS	Contact for details

Quality Control

Our 2-Fluoro-6-(Pyrrolidin-1-Yl)-4-((Trimethylsilyl)-Ethynyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.