Description

(Trans)-1-tert-Butyl 3-Methyl 4-(2-Fluoro-6-(3-(Hydroxymethyl)Pyrrolidin-1-Yl)Pyridin-3-Yl)Pyrrolidine-1,3-dicarboxylate is a high-purity, advanced pharmaceutical intermediate designed for complex synthesis pathways. This compound matters because it provides a critical, structurally defined building block essential for the research and development of novel active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers focused on developing next-generation therapeutics, particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of potential drug candidates.
• API Development: Used in research for constructing complex molecular architectures targeting various disease pathways.
• Medicinal Chemistry Research: Provides a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Employed in route scouting and scale-up studies for the production of investigational new drugs.
• Bioconjugation & Prodrug Synthesis: The functional groups present make it suitable for designing targeted drug delivery systems.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis for the pharmaceutical industry.

Basic Information

Product Name	(Trans)-1-tert-Butyl 3-Methyl 4-(2-Fluoro-6-(3-(Hydroxymethyl)Pyrrolidin-1-Yl)Pyridin-3-Yl)Pyrrolidine-1,3-dicarboxylate
CAS No.	1228663-93-1
Molecular Formula	C22H32FN3O5
Molecular Weight	437.51 g/mol
Synonyms	1-(1,1-Dimethylethyl) 3-Methyl (3R,4R)-4-[2-Fluoro-6-[(3R)-3-(Hydroxymethyl)-1-Pyrrolidinyl]-3-Pyridinyl]-3-Pyrrolidinedicarboxylate; (3R,4R)-1-tert-Butyl 3-Methyl 4-(2-Fluoro-6-((R)-3-(Hydroxymethyl)Pyrrolidin-1-yl)Pyridin-3-yl)Pyrrolidine-1,3-dicarboxylate; trans-1-Boc-3-Methyl 4-(2-Fluoro-6-(3-Hydroxymethylpyrrolidin-1-yl)Pyridin-3-yl)Pyrrolidine-1,3-dicarboxylate; UNII-7V8R8N81Q2; 7V8R8N81Q2; AOB67729; BCP31933; SCHEMBL23306211
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support compliance with ICH guidelines for impurities and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive; the container should be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.