Description

(S)-3-(4-Chloro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral piperazine derivative and a crucial advanced pharmaceutical intermediate. Its value lies in providing a stereochemically defined building block for the synthesis of complex bioactive molecules, ensuring the final product's desired pharmacological activity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those working on central nervous system (CNS) agents, receptor modulators, and other specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially for neurological and psychiatric disorders.
• Drug Discovery & Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and as a core scaffold for designing new chemical entities with targeted receptor affinity.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced pesticides and herbicides that require specific stereochemistry for efficacy.
• Chemical Research & Development: Employed in academic and industrial labs for methodological studies in asymmetric synthesis and heterocyclic chemistry.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) producing bespoke compounds for client projects.

Basic Information

Product Name	(S)-3-(4-Chloro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1228561-86-1
Molecular Formula	C15H21ClN2O2
Molecular Weight	296.79 g/mol
Synonyms	(S)-3-(4-Chlorophenyl)piperazine-1-carboxylic acid tert-butyl ester; tert-Butyl (S)-3-(4-chlorophenyl)piperazine-1-carboxylate; (S)-1-Boc-3-(4-chlorophenyl)piperazine; (S)-N-Boc-3-(4-Chlorophenyl)piperazine; (S)-3-(p-Chlorophenyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; BOC-(S)-3-(4-Chloro-Phenyl)-Piperazine; (S)-3-(4-Chloro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (S)-3-(4-Chloro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation via spectroscopic methods. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profile, and other critical parameters to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Maximum Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.