Description

(2R)-2-(5-Bromo-2-Fluorophenyl)Pyrrolidine is a high-purity chiral pyrrolidine derivative, a critical building block in modern pharmaceutical and agrochemical research. Its value lies in its unique stereochemistry and halogenated aromatic structure, which are essential for creating molecules with specific biological activity. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical industry for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery.
• Agrochemical Synthesis: Used as a precursor in the development of advanced pesticides and herbicides, leveraging its halogenated phenyl group for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes to study biological pathways and enzyme functions.
• Material Science: Potential use as a monomer or functional additive in the synthesis of specialty polymers with specific optical or electronic properties.

Basic Information

Product Name	(2R)-2-(5-Bromo-2-Fluorophenyl)Pyrrolidine
CAS No.	1228561-80-5
Molecular Formula	C10H11BrFN
Molecular Weight	244.11 g/mol
Synonyms	(R)-2-(5-Bromo-2-fluorophenyl)pyrrolidine; (2R)-2-(5-Bromo-2-fluorophenyl)-1-azacyclopentane; 5-Bromo-2-fluoro-α-[(2R)-2-pyrrolidinyl]benzene; (R)-5-Bromo-2-fluoro-α-(2-pyrrolidinyl)benzene; (R)-2-(5-Bromo-2-fluorophenyl)pyrrolidine; 1228561-80-5; (R)-2-(5-Bromo-2-fluorophenyl)azacyclopentane
EINECS	Contact for details

Quality Control

Our (2R)-2-(5-Bromo-2-Fluorophenyl)Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with research-grade and GMP-starting material standards where applicable. Certificates of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.