Description

(R)-3-(4-Chloro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, chiral piperazine derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules with targeted biological activity. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of central nervous system (CNS) active drugs, including potential antipsychotics and antidepressants.
• Agrochemical Research: Building block for developing novel pesticides and herbicides with specific chiral activity.
• Ligand Synthesis: Used in the preparation of chiral ligands for asymmetric catalysis.
• Chemical Biology Probes: Serves as a core structure for designing molecular probes to study biological pathways.
• Custom Synthesis: Employed in contract research and manufacturing (CRAM) for client-specific molecule development.
• Academic Research: Utilized in university and institutional labs for methodological development in synthetic organic chemistry.

Basic Information

Product Name	(R)-3-(4-Chloro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1228556-99-7
Molecular Formula	C15H21ClN2O2
Molecular Weight	296.79 g/mol
Synonyms	tert-Butyl (R)-3-(4-chlorophenyl)piperazine-1-carboxylate; (R)-1-Boc-3-(4-chlorophenyl)piperazine; (R)-3-(4-Chlorophenyl)-1-(tert-butoxycarbonyl)piperazine; (R)-N-Boc-3-(4-chlorophenyl)piperazine; (R)-1-N-Boc-3-(4-chlorophenyl)piperazine; (R)-3-(p-Chlorophenyl)piperazine-1-carboxylic acid tert-butyl ester; (R)-3-(4-Chlorophenyl)piperazine-1-Boc
EINECS	Contact for details

Quality Control

Our (R)-3-(4-Chloro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.