Description

tert-Butyl 4-Bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a brominated pyrrolopyridine core protected by a tert-butoxycarbonyl (Boc) group. This compound matters as a critical building block for medicinal chemists, enabling the precise synthesis of complex molecules targeting various therapeutic areas. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other small-molecule drugs, where its reactive bromine atom allows for further functionalization via cross-coupling reactions. Our supply ensures consistent quality and reliable availability for global R&D and scale-up projects.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for oncology and antiviral therapies.
• Kinase Inhibitor Development: Serves as a core scaffold for designing and synthesizing novel protein kinase inhibitors due to the privileged pyrrolopyridine structure.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Cross-Coupling Reactions: The bromine substituent at the 4-position is amenable to Suzuki, Stille, and Buchwald-Hartwig amination reactions for introducing diverse aryl, heteroaryl, or amine functionalities.
• Boc-Protected Amine Synthesis: The tert-butyl carbamate (Boc) group provides a protected amine handle that can be deprotected under mild acidic conditions to generate a free NH for further derivatization.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	tert-Butyl 4-Bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
CAS No.	1228014-35-4
Molecular Formula	C12H13BrN2O2
Molecular Weight	297.15 g/mol
Synonyms	1-Boc-4-Bromo-7-azaindole; 4-Bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester; 4-Bromo-1-(tert-butoxycarbonyl)-1H-pyrrolo[2,3-b]pyridine; 4-Bromo-1-Boc-7-azaindole; tert-Butyl 4-bromo-7-azaindole-1-carboxylate; 4-Bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylic acid 1,1-dimethylethyl ester; 1228014-35-4
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Bromo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.