Description

(6As-Trans)-11-Chloro-6,6A,7,8,9,13B-Hexahydro-7-Methyl-5H-Benzo[D]Naphth[2,1-B]Azepin-12-Ol Hydrobromide is a high-purity, complex organic salt with the CAS number 1227675-51-5. This compound is a critical advanced pharmaceutical intermediate or reference standard for research and development in medicinal chemistry. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those targeting neurological or oncological pathways.
• Medicinal Chemistry Research: Used as a core scaffold or precursor for structure-activity relationship (SAR) studies and lead optimization.
• Reference Standard: Serves as a high-purity analytical standard for quality control, method development, and regulatory submissions.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and novel synthetic methodologies.
• Biochemical Tool Compound: Potential use in probing biological systems and validating new therapeutic targets in preclinical models.

Basic Information

Product Name	(6As-Trans)-11-Chloro-6,6A,7,8,9,13B-Hexahydro-7-Methyl-5H-Benzo[D]Naphth[2,1-B]Azepin-12-Ol Hydrobromide
CAS No.	1227675-51-5
Molecular Formula	C20H22ClNO • HBr
Molecular Weight	424.76 g/mol (for hydrobromide salt)
Synonyms	11-Chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphtho[2,1-b]azepin-12-ol hydrobromide; (6aR,13bS)-11-Chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphtho[2,1-b]azepin-12-ol hydrobromide; Trans-11-Chloro-7-methyl-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]naphtho[2,1-b]azepin-12-ol HBr; Benzonaphthazepin-ol hydrobromide derivative; CAS 1227675-51-5
EINECS	Contact for details

Quality Control

Our (6As-Trans)-11-Chloro-6,6A,7,8,9,13B-Hexahydro-7-Methyl-5H-Benzo[D]Naphth[2,1-B]Azepin-12-Ol Hydrobromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm
Assay (Titration)	97.0% - 103.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.