Description

4-Bromo-2,3-difluoropyridine is a high-purity halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine and fluorine substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoropyridine core contributes to bioactivity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials that require halogenated heterocyclic components.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromine atom.

Basic Information

Product Name	4-Bromo-2,3-difluoropyridine
CAS No.	1227597-53-6
Molecular Formula	C5H2BrF2N
Molecular Weight	193.98 g/mol
Synonyms	2,3-Difluoro-4-bromopyridine; 4-Bromo-2,3-difluoropyridine; 4-Bromo-2,3-difluoropyridine; Pyridine, 4-bromo-2,3-difluoro-; 1227597-53-6
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,3-difluoropyridine is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems are designed to meet the stringent requirements of research and development as well as scale-up production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.