Description

Methyl 2-Methoxy-6-(Trifluoromethyl)Isonicotinate is a high-value, multi-functional chemical intermediate characterized by its trifluoromethyl and methoxy-substituted pyridine core. This compound matters for its role in facilitating the synthesis of complex molecules, particularly in the development of novel active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine-containing motifs to enhance the biological activity and metabolic stability of their target compounds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs), due to its electron-deficient aromatic system.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Methyl 2-Methoxy-6-(Trifluoromethyl)Isonicotinate
CAS No.	1227594-91-3
Molecular Formula	C9H8F3NO3
Molecular Weight	235.16 g/mol
Synonyms	Methyl 2-methoxy-6-(trifluoromethyl)pyridine-4-carboxylate; 2-Methoxy-6-(trifluoromethyl)isonicotinic acid methyl ester; 4-Pyridinecarboxylic acid, 2-methoxy-6-(trifluoromethyl)-, methyl ester; 6-(Trifluoromethyl)-2-methoxyisonicotinic acid methyl ester; Methyl 6-(trifluoromethyl)-2-methoxypyridine-4-carboxylate; CAS 1227594-91-3
EINECS	Contact for details

Quality Control

Our Methyl 2-Methoxy-6-(Trifluoromethyl)Isonicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your most critical synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.