Description

Methyl 3-Fluoro-2-(Trifluoromethyl)Isonicotinate is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethyl groups, is engineered to impart desirable properties such as metabolic stability and enhanced lipophilicity to target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing next-generation active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine atoms contribute to biological activity and environmental persistence.
• Material Science Precursor: Serves as a starting material for synthesizing specialty chemicals, including liquid crystals and functional polymers with specific electronic properties.
• Chemical Biology Probe Development: Employed in medicinal chemistry to create molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital component for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke fluorination and heterocyclic chemistry services.

Basic Information

Product Name	Methyl 3-Fluoro-2-(trifluoromethyl)isonicotinate
CAS No.	1227594-82-2
Molecular Formula	C9H5F4NO2
Molecular Weight	235.13 g/mol
Synonyms	3-Fluoro-2-(trifluoromethyl)isonicotinic acid methyl ester; Methyl 3-fluoro-2-(trifluoromethyl)pyridine-4-carboxylate; 4-Pyridinecarboxylic acid, 3-fluoro-2-(trifluoromethyl)-, methyl ester; 1227594-82-2; 3-Fluoro-2-trifluoromethylisonicotinic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 3-Fluoro-2-(Trifluoromethyl)Isonicotinate adheres to stringent quality management protocols. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.