Description

3-Fluoro-5-(Trifluoromethyl)Pyridine-2-Acetonitrile is a high-value, multi-functional fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and a trifluoromethyl group on the pyridine ring, makes it an essential intermediate for creating compounds with tailored electronic and steric properties. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Employed in the creation of specialty chemicals, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring the introduction of a fluorinated pyridine-acetonitrile moiety.

Basic Information

Product Name	3-Fluoro-5-(Trifluoromethyl)Pyridine-2-Acetonitrile
CAS No.	1227592-18-8
Molecular Formula	C8H4F4N2
Molecular Weight	204.13 g/mol
Synonyms	2-(3-Fluoro-5-(trifluoromethyl)pyridin-2-yl)acetonitrile; 3-Fluoro-5-trifluoromethyl-2-pyridineacetonitrile; 2-Pyridineacetonitrile, 3-fluoro-5-(trifluoromethyl)-; (3-Fluoro-5-(trifluoromethyl)pyridin-2-yl)acetonitrile
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-(Trifluoromethyl)Pyridine-2-Acetonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in cGMP and ISO-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.