Description

2-Chloromethyl-3-Bromo-6-(Trifluoromethyl)Pyridine is a high-value, multi-functional halogenated pyridine derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its molecular architecture, featuring chloromethyl, bromo, and trifluoromethyl substituents, makes it an exceptionally versatile building block for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its reactive sites enable precise structural modifications.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of receptor modulators and enzyme inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyridine core and halogen substituents.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromo and chloromethyl groups make it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Fluorine Chemistry: The trifluoromethyl group provides a source of fluorine atoms, making it valuable for synthesizing compounds with enhanced metabolic stability, lipophilicity, and bioavailability.
• Ligand and Catalyst Development: Used to create novel pyridine-based ligands for transition metal catalysis in asymmetric synthesis.

Basic Information

Product Name	2-Chloromethyl-3-Bromo-6-(Trifluoromethyl)Pyridine
CAS No.	1227585-26-3
Molecular Formula	C7H4BrClF3N
Molecular Weight	274.47 g/mol
Synonyms	3-Bromo-2-(chloromethyl)-6-(trifluoromethyl)pyridine; 2-(Chloromethyl)-3-bromo-6-(trifluoromethyl)pyridine; 6-(Trifluoromethyl)-3-bromo-2-pyridinemethanol, chloromethyl ether; Pyridine, 3-bromo-2-(chloromethyl)-6-(trifluoromethyl)-; 1227585-26-3
EINECS	Contact for details

Quality Control

Every batch of 2-Chloromethyl-3-Bromo-6-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard quality commitment includes comprehensive analysis via HPLC, GC, NMR, and MS to verify the product meets exacting specifications for research and process development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.