Description

4-(Chloromethyl)-5-Fluoropyridin-2-Ol is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its bifunctional chloromethyl and hydroxyl groups make it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Building block for developing new-generation herbicides, fungicides, and insecticides that leverage the fluoropyridine scaffold for enhanced bioactivity and environmental profile.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Research: Intermediate for synthesizing functionalized polymers, liquid crystals, or organic electronic materials requiring specific halogen and heterocyclic motifs.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	4-(Chloromethyl)-5-Fluoropyridin-2-Ol
CAS No.	1227584-62-4
Molecular Formula	C6H5ClFNO
Molecular Weight	161.56 g/mol
Synonyms	5-Fluoro-4-(chloromethyl)pyridin-2-ol; 2-Hydroxy-5-fluoro-4-(chloromethyl)pyridine; 4-(Chloromethyl)-5-fluoro-2-pyridinol; 5-Fluoro-4-(chloromethyl)-2-pyridone; 2-Pyridinol, 5-fluoro-4-(chloromethyl)-; 4-Chloromethyl-5-fluoropyridin-2-ol
EINECS	Contact for details

Quality Control

Our production of 4-(Chloromethyl)-5-Fluoropyridin-2-Ol adheres to stringent quality management protocols. Each batch is characterized and tested to ensure identity, purity, and consistency, with specifications tailored to meet the rigorous demands of pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (by IR, NMR), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.