Description

3-Hydroxy-6-(Trifluoromethyl)Pyridine-2-Carbonitrile is a high-value, multi-functional heterocyclic building block characterized by its trifluoromethyl and nitrile substituents. This compound is essential for medicinal chemistry and agrochemical research, where its unique scaffold enables the synthesis of novel active ingredients with enhanced properties. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group often improves metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating novel ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs), due to its electron-withdrawing groups.
• Fluorine Chemistry Building Block: Critical for introducing the trifluoromethyl moiety into more complex molecules, a common strategy in modern drug design to modulate lipophilicity and metabolic profile.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects and scale-up activities.

Basic Information

Product Name	3-Hydroxy-6-(Trifluoromethyl)Pyridine-2-Carbonitrile
CAS No.	1227582-76-4
Molecular Formula	C7H3F3N2O
Molecular Weight	188.11 g/mol
Synonyms	2-Cyano-3-hydroxy-6-(trifluoromethyl)pyridine; 6-(Trifluoromethyl)-2-pyridinecarbonitrile, 3-hydroxy-; 3-Hydroxy-6-trifluoromethylpicolinonitrile; 3-Hydroxy-6-(trifluoromethyl)-2-pyridinecarbonitrile; 3-Hydroxy-6-(trifluoromethyl)picolinonitrile; 2-Pyridinecarbonitrile, 3-hydroxy-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-6-(Trifluoromethyl)Pyridine-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.