Description

5-Amino-6-Chloropyridin-2-Ol is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique molecular structure, featuring both amino and chloro substituents on the pyridine core, makes it a critical intermediate for constructing complex pharmacologically active molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its halogenated pyridine scaffold.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials, dyes, and photoactive compounds.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic and R&D Laboratories: Used in medicinal chemistry programs for hit-to-lead optimization and structure-activity relationship (SAR) studies.

Basic Information

Product Name	5-Amino-6-Chloropyridin-2-Ol
CAS No.	1227581-42-1
Molecular Formula	C5H5ClN2O
Molecular Weight	144.56 g/mol
Synonyms	6-Chloro-5-aminopyridin-2-ol; 2-Hydroxy-5-amino-6-chloropyridine; 5-Amino-6-chloro-2-pyridinol; 6-Chloro-2-hydroxy-5-aminopyridine; 5-Amino-6-chloro-2(1H)-pyridinone; 6-Chloro-5-amino-2-pyridone; 2-Pyridinol, 5-amino-6-chloro-; 5-Amino-6-chloro-2-hydroxypyridine
EINECS	Contact for details

Quality Control

Every batch of 5-Amino-6-Chloropyridin-2-Ol is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure consistency and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and physical characteristics. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Single impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.