Description

3-(Bromomethyl)-5-(Trifluoromethyl)Pyridine is a versatile and highly functionalized pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic combination of a reactive bromomethyl group and a stable trifluoromethyl group, enabling precise molecular modifications. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to construct advanced pyridine-based herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a starting material for creating novel nitrogen-containing ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials due to its unique electronic properties.
• Cross-Coupling Reactions: The bromomethyl moiety acts as an excellent electrophile in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions for carbon-carbon bond formation.
• Fluorinated Compound Libraries: A valuable scaffold for constructing diverse libraries of fluorinated compounds for high-throughput screening in drug discovery.

Basic Information

Product Name	3-(Bromomethyl)-5-(Trifluoromethyl)Pyridine
CAS No.	1227574-31-3
Molecular Formula	C7H5BrF3N
Molecular Weight	240.02 g/mol
Synonyms	5-(Trifluoromethyl)-3-(bromomethyl)pyridine; 3-Bromomethyl-5-trifluoromethylpyridine; (5-Trifluoromethyl-3-pyridyl)methyl bromide; Pyridine, 3-(bromomethyl)-5-(trifluoromethyl)-; 3-Pyridinemethanol, 5-(trifluoromethyl)-, bromide
EINECS	Contact for details

Quality Control

Our production of 3-(Bromomethyl)-5-(Trifluoromethyl)Pyridine adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical parameters. Our quality system is designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.