Description

4-Methoxy-5-Trifluoromethyl-Pyridin-2-Ylamine is a high-purity, multi-functional pyridine derivative building block essential for advanced organic synthesis. Its unique trifluoromethyl and methoxy substitution pattern makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine-containing motifs into their molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent for creating specialty polymers and liquid crystals with tailored properties.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.
• Fluorine Chemistry: An important substrate for studying structure-activity relationships (SAR) in fluorinated heterocyclic compounds.

Basic Information

Product Name	4-Methoxy-5-Trifluoromethyl-Pyridin-2-Ylamine
CAS No.	1227571-99-4
Molecular Formula	C8H7F3N2O
Molecular Weight	204.15 g/mol
Synonyms	2-Amino-4-methoxy-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-4-methoxypyridin-2-amine; 4-Methoxy-5-(trifluoromethyl)pyridin-2-amine; 4-Methoxy-5-trifluoromethyl-2-aminopyridine; 2-Pyridinamine, 4-methoxy-5-(trifluoromethyl)-; 4-Methoxy-5-trifluoromethyl-2-pyridinamine
EINECS	Contact for details

Quality Control

Our 4-Methoxy-5-Trifluoromethyl-Pyridin-2-Ylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.