Description

2-Amino-3-Fluoro-4-(Trifluoromethyl)Pyridine is a high-purity, multi-fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both amino and trifluoromethyl substituents, makes it an invaluable intermediate for introducing fluorine atoms into complex molecular architectures. This compound is primarily sought after by pharmaceutical and agrochemical research & development teams for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorine atoms improve lipophilicity and biological activity.
• Material Science Precursor: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials requiring fluorinated aromatic components.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Fluorine Chemistry: Acts as a fundamental reagent for introducing the 4-(trifluoromethyl)pyridine motif into more complex molecules via cross-coupling and functional group transformations.

Basic Information

Item	Details
Product Name	2-Amino-3-Fluoro-4-(Trifluoromethyl)Pyridine
CAS No.	1227514-27-3
Molecular Formula	C7H4F4N2
Molecular Weight	192.12 g/mol
Synonyms	3-Fluoro-4-(trifluoromethyl)pyridin-2-amine; 2-Amino-3-fluoro-4-trifluoromethylpyridine; 4-(Trifluoromethyl)-3-fluoropyridin-2-amine; 2-Pyridinamine, 3-fluoro-4-(trifluoromethyl)-; 3-Fluoro-4-(trifluoromethyl)-2-aminopyridine; 2-Amino-3-fluoro-4-(trifluoromethyl)pyridine; 1227514-27-3 (CAS)
EINECS	Contact for details

Quality Control

Our 2-Amino-3-Fluoro-4-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.