Description

3-Chloromethyl-5-Fluoro-2-Methoxy-Pyridine is a high-value, multi-functional heterocyclic building block. This compound is critical for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, due to its reactive chloromethyl and fluorine substituents. It is primarily sought after by research chemists and process development scientists for constructing active pharmaceutical ingredients (APIs) and advanced intermediates. The compound's unique structure enables precise molecular modifications essential for modern drug discovery and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Material Science Research: Serves as a precursor for creating functionalized pyridine derivatives used in ligands for catalysis or in organic electronic materials.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic & R&D Laboratories: Employed in methodological studies and for exploring new chemical reactions in heterocyclic and fluoroorganic chemistry.

Basic Information

Product Name	3-Chloromethyl-5-Fluoro-2-Methoxy-Pyridine
CAS No.	1227496-70-9
Molecular Formula	C7H7ClFNO
Molecular Weight	175.59 g/mol
Synonyms	5-Fluoro-2-methoxy-3-(chloromethyl)pyridine; 2-Methoxy-5-fluoro-3-pyridinemethanol, chloromethyl ether; 3-(Chloromethyl)-5-fluoro-2-methoxypyridine; 5-Fluoro-2-methoxy-3-pyridylmethyl chloride; (5-Fluoro-2-methoxypyridin-3-yl)methyl chloride; 2-Methoxy-5-fluoro-3-(chloromethyl)pyridine
EINECS	Contact for details

Quality Control

Our 3-Chloromethyl-5-Fluoro-2-Methoxy-Pyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We adhere to cGMP principles where applicable to support our customers' regulatory and compliance needs in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.