Description

1-(Phenylsulphonyl)-5-Cyano-2-Iodo-7-Azaindole is a high-purity, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is valued for its unique molecular architecture, which incorporates a sulfonyl group, a cyano substituent, and an iodine atom on a 7-azaindole core, making it a versatile intermediate for constructing complex molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, catalyst development, and material science. The CAS number for this compound is 1227269-21-7.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly kinase inhibitors and other targeted therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for hit-to-lead optimization.
• Agrochemical Development: Serves as a precursor in the creation of new active ingredients for crop protection products.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form new carbon-carbon bonds.
• Material Science: Potential use in the development of organic electronic materials and photoactive compounds.
• Chemical Biology Probes: Can be utilized to develop molecular probes for studying biological pathways and protein functions.

Basic Information

Product Name	1-(Phenylsulphonyl)-5-Cyano-2-Iodo-7-Azaindole
CAS No.	1227269-21-7
Molecular Formula	C14H8IN3O2S
Molecular Weight	409.20 g/mol
Synonyms	1-(Phenylsulfonyl)-5-cyano-2-iodo-1H-pyrrolo[2,3-b]pyridine; 2-Iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile; 5-Cyano-2-iodo-1-(phenylsulfonyl)-7-azaindole; 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 2-iodo-1-(phenylsulfonyl)-; 1227269-21-7; 1-(Benzenesulfonyl)-5-cyano-2-iodo-7-azaindole
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulphonyl)-5-Cyano-2-Iodo-7-Azaindole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. Keep the container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.