Description

1-Benzenesulfonyl-5-Iodo-1H-Pyrrolo[2,3-B]Pyridine is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for researchers and manufacturers requiring precise molecular scaffolds to develop novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily utilized in medicinal chemistry for drug discovery, particularly in the synthesis of kinase inhibitors and other targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially kinase inhibitors for oncology and inflammatory diseases.
• Agrochemical Research: Used in the development of new herbicides and pesticides, leveraging its unique pyrrolopyridine core.
• Material Science: Serves as a building block for creating organic electronic materials and functional dyes.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions.
• Chemical Biology: Employed in the design and synthesis of molecular probes and bio-conjugates for target identification and validation.
• Academic & Contract Research: Essential for synthetic methodology development and exploring new chemical space in university and CRO laboratories.

Basic Information

Product Name	1-Benzenesulfonyl-5-Iodo-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1227268-94-1
Molecular Formula	C13H9IN2O2S
Molecular Weight	384.19 g/mol
Synonyms	5-Iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-iodo-1-(phenylsulfonyl)-; 5-Iodo-1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine; 1-(Phenylsulfonyl)-5-iodo-1H-pyrrolo[2,3-b]pyridine; 5-Iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridine (common name variant); Benzenesulfonyl 5-iodopyrrolopyridine; CAS 1227268-94-1
EINECS	Contact for details

Quality Control

Our 1-Benzenesulfonyl-5-Iodo-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance in cGMP and ISO 9001 environments for pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.