Description

tert-Butyl 3-(3-Chloropyrazin-2-yl)azetidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its azetidine and chloropyrazine functional groups. This compound is of significant value for its role as a key building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially those targeting protein kinases.
• Medicinal Chemistry Research: Used extensively in research and development (R&D) for structure-activity relationship (SAR) studies and lead optimization.
• API Synthesis: Incorporated into the synthetic pathways for Active Pharmaceutical Ingredients (APIs) under current Good Manufacturing Practice (cGMP) conditions.
• Bioconjugation & Probe Development: Utilized in the creation of chemical probes for biochemical and cellular assays due to its reactive handles.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	tert-Butyl 3-(3-Chloropyrazin-2-yl)azetidine-1-carboxylate
CAS No.	1227068-60-1
Molecular Formula	C12H16ClN3O2
Molecular Weight	269.73 g/mol
Synonyms	1-Boc-3-(3-chloropyrazin-2-yl)azetidine; 3-(3-Chloro-2-pyrazinyl)-1-azetidinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-3-(3-chloropyrazin-2-yl)azetidine; tert-Butyl 3-(3-chloro-2-pyrazinyl)azetidine-1-carboxylate; Azetidine-1-carboxylic acid, 3-(3-chloro-2-pyrazinyl)-, 1,1-dimethylethyl ester; 1227068-60-1; Boc-3-(3-chloropyrazin-2-yl)azetidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(3-Chloropyrazin-2-yl)azetidine-1-carboxylate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All materials are supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques (HPLC, GC, NMR). We adhere to relevant quality guidelines to support our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.