Description

Omarigliptin (MK-3102) is a potent, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor developed for the treatment of type 2 diabetes. Its primary value lies in its once-weekly dosing regimen, offering significant convenience and improved patient adherence compared to daily therapies. This high-purity active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers engaged in the research, development, and production of innovative antidiabetic medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of once-weekly oral antidiabetic drugs.
• Clinical Research: Serves as a reference standard and key material in preclinical and clinical studies for diabetes.
• Drug Development: Used in the development of new fixed-dose combination therapies for type 2 diabetes management.
• Analytical Standard: Employed as a high-purity standard for quality control and analytical method development (HPLC, LC-MS).
• Mechanistic Studies: A critical tool for biochemical and pharmacological research into DPP-4 enzyme inhibition and glucose metabolism.

Basic Information

Product Name	Omarigliptin (MK-3102)
CAS No.	1226781-44-7
Molecular Formula	C17H19F3N4O2
Molecular Weight	368.35 g/mol
Synonyms	MK-3102; MK3102; (2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-methylsulfonyl-5-pyrimidinyl)-3,4-dihydro-2H-pyrrole-3-carbonitrile; 2-((2R,3S,5R)-3-Cyano-5-(2-methylsulfonylpyrimidin-5-yl)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-2-oxoethyl acetate; JANUVIA analogue (weekly); DPP-4 Inhibitor MK-3102
EINECS	Contact for details

Quality Control

Our Omarigliptin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and potency meet stringent pharmaceutical standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specifications for assay, related substances, residual solvents, and heavy metals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.