Description

1-Piperazinecarboxylic Acid, 4-(2,2-Difluoroethyl)-, 1,1-Dimethylethyl Ester is a high-value, protected piperazine derivative that serves as a critical building block in modern synthetic chemistry. Its core value lies in its role as a versatile intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require reliable, high-purity intermediates for advanced synthesis.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the difluoroethyl moiety can impart desirable biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics and Bioactive Molecule Construction: The protected carboxylic acid and substituted piperazine core are valuable for designing peptide analogs and other bioactive compounds.
• Material Science Research: Potential use as a monomer or functional additive in the synthesis of specialized polymers with unique properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in multi-step custom synthesis projects.

Basic Information

Product Name	1-Piperazinecarboxylic Acid, 4-(2,2-Difluoroethyl)-, 1,1-Dimethylethyl Ester
CAS No.	1225380-87-9
Molecular Formula	C11H20F2N2O2
Molecular Weight	262.29 g/mol
Synonyms	tert-Butyl 4-(2,2-difluoroethyl)piperazine-1-carboxylate; 4-(2,2-Difluoroethyl)piperazine-1-carboxylic acid tert-butyl ester; 1-Boc-4-(2,2-difluoroethyl)piperazine; Boc-4-(2,2-difluoroethyl)piperazine; N-Boc-4-(2,2-difluoroethyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(2,2-difluoroethyl)piperazine; Piperazine, 4-(2,2-difluoroethyl)-, 1-(1,1-dimethylethyl) 1-carbamate
EINECS	Contact for details

Quality Control

Our 1-Piperazinecarboxylic Acid, 4-(2,2-Difluoroethyl)-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring material that meets ICH guidelines for impurities and stability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.