Description

1-(2,2-Difluoro-Ethyl)-Piperazine 2Hcl CAS NO 1225276-98-1 is a high-purity, specialized piperazine derivative used as a critical building block in advanced organic synthesis. This compound is valued for its role in introducing the difluoroethyl-piperazine moiety, which can significantly alter the physicochemical and pharmacological properties of target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the difluoroethyl group enhances bioavailability and stability.
• Ligand and Catalyst Development: Serves as a precursor for constructing complex ligands used in catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Research: Employed as a probe or building block in medicinal chemistry for structure-activity relationship (SAR) studies.
• Custom Synthesis and Contract Manufacturing: A critical raw material for custom synthesis organizations (CSOs) producing bespoke compounds for client projects.

Basic Information

Product Name	1-(2,2-Difluoro-Ethyl)-Piperazine 2Hcl
CAS No.	1225276-98-1
Molecular Formula	C6H12F2N2 • 2HCl
Molecular Weight	231.09 g/mol
Synonyms	1-(2,2-Difluoroethyl)piperazine dihydrochloride; 1-(2,2-Difluoroethyl)piperazine hydrochloride (1:2); Piperazine, 1-(2,2-difluoroethyl)-, dihydrochloride; 1225276-98-1; 1-(2,2-Difluoroethyl)piperazine HCl; 2,2-Difluoroethyl-piperazine dihydrochloride
EINECS	Contact for details

Quality Control

Our 1-(2,2-Difluoro-Ethyl)-Piperazine 2Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.