Description

6-Chloro-n-Methoxy-n-Methylpyrazine-2-Carboxamide is a high-purity, advanced pharmaceutical intermediate with a distinct pyrazine core structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic chemistry. Pharmaceutical R&D teams and fine chemical manufacturers need it to develop next-generation drug candidates, leveraging its unique functional groups for targeted molecular construction.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of complex drug molecules, especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Serves as a key scaffold for developing new generation pesticides and herbicides with specific modes of action.
• Chemical Biology & Proteomics: Used in the design and synthesis of molecular probes and enzyme inhibitors for biochemical pathway studies.
• Material Science: Potential building block for specialty polymers and organic electronic materials due to its electron-deficient pyrazine ring.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and scale-up services for the life sciences industry.
• Academic Research: Utilized in university and institutional labs for methodological development in heterocyclic and medicinal chemistry.

Basic Information

Item	Details
Product Name	6-Chloro-n-Methoxy-n-Methylpyrazine-2-Carboxamide
CAS No.	1223444-91-4
Molecular Formula	C8H10ClN3O2
Molecular Weight	215.64 g/mol
Synonyms	6-Chloro-N-methoxy-N-methylpyrazine-2-carboxamide; 2-Pyrazinecarboxamide, 6-chloro-N-methoxy-N-methyl-; 6-Chloro-N-methoxy-N-methyl-2-pyrazinecarboxamide; 6-Chloro-N-methoxy-N-methylpyrazinecarboxamide; 6-Chloro-N-methoxy-N-methyl-2-pyrazinecarboxamide; 6-Chloro-N-methoxy-N-methylpyrazine-2-carboxylic acid amide; 6-Chloro-N-methoxy-N-methylpicolinamide (incorrect but common misnomer); 6-Chloro-N-OMe-N-Me-pyrazine-2-carboxamide
EINECS	Contact for details

Quality Control

Our 6-Chloro-n-Methoxy-n-Methylpyrazine-2-Carboxamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Production adheres to cGMP (current Good Manufacturing Practice) guidelines where applicable. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, verified by advanced analytical techniques including HPLC, GC, NMR, and MS. We support our clients' regulatory submissions with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.