Description

1-(6-Fluoro-3,4-dihydro-1,8-naphthyridin-1(2H)-yl)-2,2-dimethylpropan-1-one is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound matters because it provides a critical, structurally-defined building block essential for research and development in modern medicinal chemistry. It is primarily needed by pharmaceutical manufacturers, biotechnology R&D labs, and fine chemical synthesis specialists working on novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop novel bioactive molecules.
• API Synthesis: Serves as a crucial building block in the multi-step synthesis of complex target molecules for preclinical and clinical studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of pharmaceutical compounds.
• Academic Research: Utilized in university and institutional labs for chemical methodology development and exploring new heterocyclic chemistry.

Basic Information

Product Name	1-(6-Fluoro-3,4-dihydro-1,8-naphthyridin-1(2H)-yl)-2,2-dimethylpropan-1-one
CAS No.	1222533-74-5
Molecular Formula	C₁₃H₁₇FN₂O
Molecular Weight	236.29 g/mol
Synonyms	1-(6-Fluoro-1,2,3,4-tetrahydro-1,8-naphthyridin-1-yl)-2,2-dimethylpropan-1-one; 2,2-Dimethyl-1-(6-fluoro-3,4-dihydro-1,8-naphthyridin-1(2H)-yl)propan-1-one; 6-Fluoro-1-(2,2-dimethylpropanoyl)-1,2,3,4-tetrahydro-1,8-naphthyridine; 1,8-Naphthyridine, 1-(2,2-dimethyl-1-oxopropyl)-6-fluoro-1,2,3,4-tetrahydro-; Pivaloyl derivative of 6-fluoro-1,2,3,4-tetrahydro-1,8-naphthyridine
EINECS	Contact for details

Quality Control

Our 1-(6-Fluoro-3,4-dihydro-1,8-naphthyridin-1(2H)-yl)-2,2-dimethylpropan-1-one is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.