Description

Evogliptin is a potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor, a key active pharmaceutical ingredient (API) in the treatment of type 2 diabetes. Its high selectivity and efficacy make it a critical component in the development of next-generation antidiabetic medications. This compound is essential for pharmaceutical manufacturers and research institutions focused on metabolic disorder therapeutics, drug formulation, and clinical research.

Application

• Pharmaceutical API: Primary active ingredient in the formulation of oral antidiabetic drugs for type 2 diabetes management.
• Drug Development & Research: Used in preclinical and clinical research to study DPP-4 inhibition mechanisms and therapeutic efficacy.
• Formulation Studies: Critical for developing stable and bioavailable solid dosage forms such as tablets and capsules.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical labs.
• Combination Therapies: Investigated for use in fixed-dose combination drugs with other antidiabetic agents.
• Metabolic Disorder Research: A tool compound for academic and industrial research into insulin secretion and glucose homeostasis.

Basic Information

Product Name	Evogliptin
CAS No.	1222102-29-5
Molecular Formula	C₁₈H₂₃FN₄O₂
Molecular Weight	346.40 g/mol
Synonyms	DA-1229; (R)-4-[(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(tert-butoxymethyl)piperazin-2-one; Evogliptin Succinate; Succinyl Evogliptin; (3R)-4-[(2R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-[(2-methylpropan-2-yl)oxymethyl]piperazin-2-one
EINECS	Contact for details

Quality Control

Our Evogliptin is manufactured under strict quality management systems, targeting purity levels suitable for pharmaceutical development. Each batch is tested to ensure identity, potency, and purity, with comprehensive impurity profiling conducted. Certificates of Analysis (COA) detailing specifications such as assay, related substances, residual solvents, and heavy metals are provided and can be tailored to meet specific pharmacopeial standards (e.g., ICH guidelines) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤20 ppm
Loss on Drying	≤0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.