Description

1-(2,5-Difluorobenzoyl)Piperazine Hydrochloride is a high-purity pharmaceutical intermediate and building block of significant interest in modern organic synthesis. This compound is valued for its role as a key precursor in the development of active pharmaceutical ingredients (APIs), particularly within medicinal chemistry research. It is primarily sought after by R&D laboratories and manufacturers in the pharmaceutical and agrochemical industries for constructing complex molecules with specific biological activity.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used extensively in research and development for structure-activity relationship (SAR) studies and lead optimization processes.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a key precursor in multi-step synthetic routes for the production of specific, high-value APIs.
• Agrochemical Research: Employed in the development of new pesticides and herbicides, leveraging the biological activity of the difluorobenzoyl-piperazine scaffold.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and target identification.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	1-(2,5-Difluorobenzoyl)Piperazine Hydrochloride
CAS No.	1221724-79-3
Molecular Formula	C11H13ClF2N2O
Molecular Weight	262.68 g/mol
Synonyms	1-(2,5-Difluorobenzoyl)piperazine hydrochloride; 1-(2,5-Difluorobenzoyl)piperazine HCl; Piperazine, 1-(2,5-difluorobenzoyl)-, hydrochloride; 2,5-Difluorophenyl(piperazin-1-yl)methanone hydrochloride; 1221724-79-3; UNII-8J2F6Q9Q1H; 8J2F6Q9Q1H; SCHEMBL2180227; AKOS025147319; A1-00317
EINECS	Contact for details

Quality Control

Our 1-(2,5-Difluorobenzoyl)Piperazine Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) guidelines where applicable, and our quality systems are designed to meet the stringent requirements of global regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.