Description

2-Amino-3-Chloro-5-(Trifluoromethyl)-Isonicotinonitrile CAS NO 1221572-26-4 is a high-value, multi-functional heterocyclic building block featuring a pyridine core substituted with amino, chloro, trifluoromethyl, and cyano groups. This compound matters for its unique molecular architecture, which provides multiple reactive sites for chemical synthesis, making it a critical intermediate for creating complex molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly those requiring the trifluoromethyl group for enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoromethyl group can improve efficacy and environmental profile.
• Material Science Research: Serves as a precursor for developing functional materials, such as organic semiconductors or metal-organic frameworks (MOFs), due to its rigid, electron-deficient core.
• Chemical Biology Probes: Employed in the creation of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Amino-3-Chloro-5-(Trifluoromethyl)-Isonicotinonitrile
CAS No.	1221572-26-4
Molecular Formula	C7H3ClF3N3
Molecular Weight	221.57 g/mol
Synonyms	2-Amino-3-chloro-5-(trifluoromethyl)pyridine-4-carbonitrile; 3-Chloro-2-amino-5-trifluoromethylisonicotinonitrile; 4-Cyano-2-amino-3-chloro-5-trifluoromethylpyridine; 2-Amino-3-chloro-5-trifluoromethyl-4-pyridinecarbonitrile; 2-Amino-3-chloro-5-(trifluoromethyl)isonicotinonitrile; 2-Amino-3-chloro-5-(trifluoromethyl)-4-pyridinecarbonitrile; 4-Pyridinecarbonitrile, 2-amino-3-chloro-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Amino-3-Chloro-5-(Trifluoromethyl)-Isonicotinonitrile is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic intermediates. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided for every shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.