Description

Methyl 3-Iodo-1H-Pyrazolo[3,4-B]Pyridine-5-Carboxylate is a high-value heterocyclic building block and advanced pharmaceutical intermediate. This compound is critical for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor programs. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors seeking to introduce specific molecular complexity into their target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds to study biological pathways and target validation.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the commercial manufacturing of APIs.
• Custom Synthesis & Contract Manufacturing: A requested building block for bespoke synthesis projects in fine chemical production.
• Agrochemical Research: Potential intermediate in the discovery of new crop protection agents with novel modes of action.

Basic Information

Product Name	Methyl 3-Iodo-1H-Pyrazolo[3,4-B]Pyridine-5-Carboxylate
CAS No.	1221288-25-0
Molecular Formula	C8H6IN3O2
Molecular Weight	303.06 g/mol
Synonyms	Methyl 3-iodo-1H-pyrazolo[3,4-b]pyridine-5-carboxylate; 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid, 3-iodo-, methyl ester; 3-Iodo-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester; Methyl 3-iodo-1H-pyrazolo[3,4-b]pyridin-5-carboxylate; 1221288-25-0; 3-Iodo-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 3-Iodo-1H-Pyrazolo[3,4-B]Pyridine-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) with full analytical data are provided and available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.