Description

6-Chloro-2-(Trifluoromethoxy)-3-(Trimethylsilyl)Pyridine is a high-value, multi-functional organosilicon pyridine derivative designed for advanced chemical synthesis. This compound is a critical building block for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, offering unique reactivity due to its trifluoromethoxy and trimethylsilyl substituents. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine and silicon functionalities into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing the trifluoromethoxy group to modulate lipophilicity, metabolic stability, and bioavailability.
• Agrochemical Synthesis: Serves as a precursor for novel herbicides, fungicides, and insecticides where the fluorine and silicon groups enhance biological activity and environmental persistence.
• Material Science Research: Used in the synthesis of advanced organic materials, including liquid crystals, organic semiconductors, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The chloro and silyl groups make it a versatile substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Hiyama).
• Fluorine Chemistry: An essential reagent for introducing the trifluoromethoxy (OCF3) moiety, a privileged structural motif in medicinal and agrochemistry.
• Protecting Group Strategy: The trimethylsilyl group can act as a protecting group for the pyridine nitrogen or be utilized in ipso-desilylation reactions.

Basic Information

Product Name	6-Chloro-2-(Trifluoromethoxy)-3-(Trimethylsilyl)Pyridine
CAS No.	1221172-02-6
Molecular Formula	C9H11ClF3NOSi
Molecular Weight	269.72 g/mol
Synonyms	3-(Trimethylsilyl)-6-chloro-2-(trifluoromethoxy)pyridine; 2-(Trifluoromethoxy)-6-chloro-3-(trimethylsilyl)pyridine; 6-Chloro-2-trifluoromethoxy-3-trimethylsilylpyridine; Pyridine, 6-chloro-2-(trifluoromethoxy)-3-(trimethylsilyl)-; CAS 1221172-02-6
EINECS	Contact for details

Quality Control

Every batch of 6-Chloro-2-(Trifluoromethoxy)-3-(Trimethylsilyl)Pyridine is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (HPLC), identity (NMR, IR), and impurity profiles. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliable performance in your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.