Description

2-Chloro-6-(Trifluoromethoxy)Isonicotinic Acid is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is valued for its unique molecular scaffold, which combines halogen and trifluoromethoxy substituents to impart specific electronic and steric properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, anti-infectives, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Material Science Research: Serves as a specialized monomer or additive in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a molecular probe or a tagging reagent in biochemical research to study protein-ligand interactions and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	2-Chloro-6-(Trifluoromethoxy)Isonicotinic Acid
CAS No.	1221171-97-6
Molecular Formula	C7H3ClF3NO3
Molecular Weight	241.55 g/mol
Synonyms	2-Chloro-6-(trifluoromethoxy)pyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 2-chloro-6-(trifluoromethoxy)-; 2-Chloro-6-(trifluoromethoxy)isonicotinate; 2-Chloro-6-trifluoromethoxyisonicotinic acid; 2-Chloro-6-(trifluoromethoxy)nicotinic acid (common misnomer); 6-Chloro-2-(trifluoromethoxy)isonicotinic acid; CTFIA (abbreviation)
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-(Trifluoromethoxy)Isonicotinic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed immediately after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.